Cellular stress causes cancer cell chemoresistance

There is a broad range of mechanisms associated with chemoresistance, many of which to date are only poorly understood. The so-called cellular stress response—a set of genetic programs that enable the cells to survive under ...

Network of protein-RNA interaction guides phase separation

St. Jude Children's Research Hospital investigators are studying the details of how phase separation leads to the formation of RNA granules, assemblies of protein and RNA that are not bound by a membrane. Their findings show ...

Molecular networks serve as cellular blueprints

Networks are at the heart of everything from communications systems to pandemics. Now researchers have found that a unique type of network also underlies the structures of critical cellular compartments known as membraneless ...

In cellular biology, mistakes can be good

Mistakes are rarely rewarded. Intuitively, one would imagine that a shoddy typist at an office who keeps generating typos would either quickly lose their job, or at least be overlooked for promotion. The idea that this person ...

Brain cells protect muscles from wasting away

While many of us worry about proteins aggregating in our brains as we age and potentially causing Alzheimer's disease or other types of neurodegeneration, we may not realize that some of the same proteins are aggregating ...

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