How E. coli defends itself against antibiotics

Imagine that you have a very sore throat. You're sick, your throat hurts, and a visit to the doctor confirms that the pain is due to a bacterial infection. You get a prescription for antibiotics, which quickly sorts out your ...

Understanding why BRCA2 is linked to cancer risk

A new study shows exactly how the gene BRCA2, linked to susceptibility to breast and ovarian cancer, functions to repair damaged DNA. By studying BRCA2 at the level of single molecules, researchers at the University of California, ...

New method for the detection of RNA viruses such as SARS-CoV-2

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the Aragon Nanoscience and Materials Institute of ...

Structural and mechanistic insight into DNA repair

DNA double-strand breaks are one of the biggest threats to the genome and a driving force of carcinogenesis. Cellular repair mechanisms such as homologous recombination are essential for the maintenance of genome stability ...

Physical mechanisms explaining DNA and RNA twist changes

The double-helix structure of DNA is deformed by environmental stimuli, which will then affect gene expression, and eventually trigger a sequence of cellular processes. Recent research led by a physicist from City University ...

Scientists use DNA origami to monitor CRISPR gene targeting

The remarkable genetic scissors called CRISPR/Cas9, the discovery that won the 2020 Nobel Prize in Chemistry, sometimes cut in places that they are not designed to target. Though CRISPR has completely changed the pace of ...

Barcoding long DNA quantifies CRISPR effects

Current sequencing techniques lack the sensitivity to detect rare gene mutations in a pool of cells, which is particularly important, for example, in early cancer detection. Now, scientists at KAUST have developed an approach, ...

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