Intestinal regeneration: Lessons from organoid research

The last decade has seen a boom in the field of organoids, miniature organs grown from stem cells in vitro. These systems recapitulate the cell type composition and numerous functions of parent organs—such as brain, kidney, ...

'Census' in the zebrafish's brain

The zebrafish is a master of regeneration: If brain cells are lost due to injury or disease, it can simply reproduce them—contrary to humans, where this only happens in the fetal stage. However, the zebrafish is evolutionarily ...

Dental stem cells can generate milk-producing cells

Stem cells of the teeth can contribute to the regeneration of non-dental organs, namely mammary glands. According to a new study from researchers at the University of Zurich, dental epithelial stem cells from mice can generate ...

When it comes to regrowing tails, neural stem cells are the key

Cut off a salamander's tail and, in a few weeks, a near-perfect replacement grows. Do the same to a lizard and a new tail will regrow, but it won't be the same as the original. By comparing tail regeneration between the two ...

Designer human tissue—coming to a lab near you

The latest issue of Philosophical Transactions B looks at the opportunities for the use of human pluripotent stem cells (PSCs), both from embryos and from the reprogramming of adult cells, as a scalable alternative to using ...

How intestinal cells renew themselves

The intestine must be able to renew itself to recover from environmental insults like bacterial infections. This renewal is made possible by a small number of intestinal stem cells which divide and produce daughter cells ...

Complete skin regeneration system of fish unraveled

Fish and amphibians such as newts can perfectly regenerate tissue without scar tissue in the event that they lose organs such as their limbs. Studying the mechanisms of regeneration and homeostasis of tissues has potential ...

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