Nanoparticles can turn off genes in bone marrow cells

Using specialized nanoparticles, MIT engineers have developed a way to turn off specific genes in cells of the bone marrow, which play an important role in producing blood cells. These particles could be tailored to help ...

Genetic origins of hybrid dysfunction

In a small pool nestled between two waterfalls in Hidalgo, Mexico, lives a population of hybrid fish—the result of many generations of interbreeding between highland and sheepshead swordtails. The lab of Molly Schumer, ...

A 'biomultimeter' to measure RNA and protein production in real-time

Builders of genetic circuits face the same quandary as builders of digital circuits: testing their designs. Yet unlike bioengineers, engineers have a simple and universal testing tool—the multimeter—that they can touch ...

Nanobodies could help CRISPR turn genes on and off

The genetic tool CRISPR has been likened to molecular scissors for its ability to snip out and replace genetic code within DNA. But CRISPR has a capability that could make it useful beyond genetic repairs. "CRISPR can precisely ...

New-found molecular signature keeps key genes ready for action

During development, scores of molecular signals prod cells to take on specialized identities and functions. In response to some of these signals, the cellular machinery awakens specific genes called 'immediate early genes' ...

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