The light of fireflies for medical diagnostics

In biology and medicine, we often need to detect biological molecules. For example, in cancer diagnostics, doctors need quick and reliable ways of knowing if tumor cells are present in the patient's body. Although such detection ...

How to reset a diseased cell

In proof-of-concept experiments, researchers at University of California, San Diego School of Medicine demonstrate the ability to tune medically relevant cell behaviors by manipulating a key hub in cell communication networks. ...

Protein threshold linked to Parkinson's disease

The circumstances in which a protein closely associated with Parkinson's Disease begins to malfunction and aggregate in the brain have been pinpointed in a quantitative manner for the first time in a new study.

How cells communicate

During embryonal development of vertebrates, signaling molecules inform each cell at which position it is located. In this way, the cell can develop its special structure and function. For the first time now, researchers ...

Signaling molecule crucial to stem cell reprogramming

While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with ...

Tracing water channels in cell surface receptors

G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in our cells, involved in signal transmission across the cell membrane. One of the biggest questions is how a signal recognized at the extracellular ...

New discovery in living cell signaling

A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant ...

Membrane proteins: Communicating with the world across the border

All living cells are held together by membranes, which provide a barrier to the transport of nutrients. They are also the communication platform connecting the outside world to the cell's interior control centers. Thousands ...

Detour leads to antibiotic resistance

Ludwig Maximilian University researchers have used cryo-electron microscopic imaging to characterize the structural alterations in the bacterial ribosome that are required for induction of resistance to the antibiotic erythromycin.

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