Protein threshold linked to Parkinson's disease

The circumstances in which a protein closely associated with Parkinson's Disease begins to malfunction and aggregate in the brain have been pinpointed in a quantitative manner for the first time in a new study.

How cells communicate

During embryonal development of vertebrates, signaling molecules inform each cell at which position it is located. In this way, the cell can develop its special structure and function. For the first time now, researchers ...

Signaling molecule crucial to stem cell reprogramming

While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with ...

Tracing water channels in cell surface receptors

G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in our cells, involved in signal transmission across the cell membrane. One of the biggest questions is how a signal recognized at the extracellular ...

An "anchor" that keeps proteins together

All organisms react to different external and internal stimuli: if, for example, the hyphae fungus Sordaria macrospora is supplied with food, it produces fruiting bodies as part of its oestrous cycle. To initiate this reaction, ...

New discovery in living cell signaling

A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant ...

Membrane proteins: Communicating with the world across the border

All living cells are held together by membranes, which provide a barrier to the transport of nutrients. They are also the communication platform connecting the outside world to the cell's interior control centers. Thousands ...

Detour leads to antibiotic resistance

Ludwig Maximilian University researchers have used cryo-electron microscopic imaging to characterize the structural alterations in the bacterial ribosome that are required for induction of resistance to the antibiotic erythromycin.

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