DNA damage is occurring in our cells all the time due to external agents, such as exposure to sun, or internal agents, like reactive oxygen species. To detect and repair DNA lesions, cells have evolved DNA damage response. ...
Cell & Microbiology
Feb 27, 2019
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4
Scientists in the University of Wisconsin-Madison Department of Biochemistry are watching evolution happen in real time.
Biotechnology
Feb 26, 2019
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6
Although many people are aware that chromosomal damage and shortening contribute to the aging process, understanding how chromosomal defects occur is about more than just finding a way to turn back the clock. Large changes ...
Cell & Microbiology
Jan 24, 2019
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5
DNA is a molecular manual that contains instructions for building life. And, like any manual, DNA isn't all that useful if it remains unopened and unread. In order to transcribe DNA, the enzyme RNA polymerase, or RNAP, must ...
Molecular & Computational biology
Jan 10, 2019
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1
Genes contain all the information needed for the functioning of cells, tissues and organs. Gene expression, meaning when and how the genes are read and executed, is thoroughly regulated like an assembly line with several ...
Cell & Microbiology
Jan 9, 2019
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4
Researchers have provided new insight on the mechanism underlying the control of gene expression in all living organisms, according to a study published today in eLife.
Cell & Microbiology
Jan 8, 2019
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100
Damage to DNA is a constant threat to cellular life, and so it is constantly monitored and detected by a family of enzymes called RNA polymerases, resulting in subsequent repair to maintain genome integrity. In a paper published ...
Biotechnology
Aug 22, 2018
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57
In eukaryotic cells, linear genetic DNA wraps around histones to form stable nucleosomes that further assemble to form chromatins. Nucleosomes represent big barriers to the transcription machine RNA polymerase.
Cell & Microbiology
Jul 23, 2018
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11
Scientists have shed light on DNA 'melting' – a crucial process fundamental to all life.
Cell & Microbiology
Jun 22, 2018
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75
When cells grow and divide to ensure a biological function—such as a properly working organ—DNA must be unwound from its typical tightly packed form and copied into RNA to create proteins. When this process goes awry—if ...
Cell & Microbiology
Jun 21, 2018
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