A new use of an old mathematical method analyzes a massive single-cell RNA sequencing experiment to explore how cells move from one state to another.
Cell & Microbiology
Feb 1, 2019
1
57
A team of New York Stem Cell Foundation (NYSCF) Research Institute scientists led by David Kahler, PhD, NYSCF Director of Laboratory Automation, have developed a new way to generate induced pluripotent stem (iPS) cell lines ...
Cell & Microbiology
Apr 3, 2013
0
1
Houston Methodist researchers have identified an immune pathway that promotes the formation of a cell that can develop into new tissues and organs.
Medical research
Mar 9, 2017
0
5
While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with ...
Cell & Microbiology
Nov 20, 2014
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0
The original iPS cells were reprogrammed by transducing four genes: OCT3/4, SOX2, KLF4, and c-MYC. Later experiments would show that c-MYC can be replaced with MYCL. Both are MYC proteins and thus oncogenes, but animal experiments ...
Cell & Microbiology
Dec 21, 2021
0
8
Cell reprogramming provides an outstanding opportunity for the artificial generation of stem cells for regenerative medicine approaches in the clinic. As current cell reprogramming methods are low in efficiency, researchers ...
Cell & Microbiology
Jul 6, 2020
0
3
Human stem cells produced through genetic reprogramming are beset by safety concerns because current techniques alter the DNA of the stem cells and use material from animals to grow them. Now, A*STAR researchers have developed ...
Cell & Microbiology
Aug 13, 2014
0
0
The effectiveness of reprogramming cells into blood cells is thought to depend on the original cell type and reprogramming method. Researchers at CiRA show this assumption is actually the result of epigenetic effects, suggesting ...
Cell & Microbiology
Jul 28, 2016
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2
A joint research team led by Dr. Akira Kunitomi, a former postdoctoral fellow at CiRA (currently a researcher at the Gladstone Institute of Cardiovascular Disease), and ID Pharma Co., Ltd., has uncovered the crucial role ...
Cell & Microbiology
May 10, 2024
0
2
Some heritable but unstable genetic mutations that are passed from parent to affected offspring may not be easy to investigate using current human-induced pluripotent stem cell (hiPSC) modeling techniques, according to research ...
Cell & Microbiology
Mar 13, 2017
0
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