Scientists at ANU and Heidelberg University in Germany have found an essential component in the DNA repair process which could open the door to the development of new cancer drugs.
Double-stranded breaks in DNA can be detected with several technologies. Doing so in plants is exceptionally difficult, but GUIDE-Seq shows promise in new studies.
Scientists have developed a method of allowing materials, commonly used in aircraft and satellites, to self-heal cracks at temperatures well below freezing.
To find out what activates SIRT6, the researchers alternately applied chemical inhibitors to human skin cells to determine which proteins were essential in getting the gene to repair the broken DNA strands. They discovered ...
Millions of human cells are constantly dividing to repair tissue damage and ensure continuity. This is one of the most complex cellular processes, and in order for it to be successful, cells must produce a copy of their genetic ...
Scientists from the University of Sussex have discovered how an enzyme, known as PARP3, helps to accelerate the repair of DNA.
Blocking a human branched DNA enzyme offers new ways of targeting a crucial enzyme family for cancer
An international team of scientists has discovered how compounds block flap endonuclease 1 (FEN1) - a crucial enzyme class in the DNA damage response and potential target for cancer treatment.
CRISPR-Cas9 is the go-to technique for knocking out genes in human cell lines to discover what the genes do, but the efficiency with which it disables genes can vary immensely.
Researchers from the Institut Jacques Monod (CNRS/University of Paris Diderot), the Institute of Biology of the Ecole Normale Supérieure (ENS/CNRS/Inserm), and the University of Bristol, have described for the first time ...
A new way of fixing inactive proteins has been discovered in an algae, which uses chloroplast extracts and light to release an interrupting sequence from a protein.