A newly discovered protein repairs DNA

Researchers from the University of Seville, in collaboration with colleagues from the Universities of Murcia and Marburg (Germany) have identified a new protein that makes it possible to repair DNA. The protein in question, ...

Histone degradation after DNA damage enhances repair

DNA damage can occur anywhere in the genome, but most DNA is wrapped around nucleosomes making it inaccessible to the repair machinery. Researchers from the Gasser group now show that DNA damage induces histone depletion, ...

RNA information transfer could be used in repairing DNA

Genomes are routinely subjected to DNA damage. But most cells have DNA repair systems that enforce genome stability and, ideally, prevent diseases like cancer. The trouble gets serious when these systems break down. When ...

Researchers create bioluminescent tag to detect DNA break repair

A new bioluminescent reporter that tracks DNA double stranded break (DSB) repair in cells has been developed by researchers from Massachusetts General Hospital (MGH) and the Academia Sinica in Taiwan. The international team's ...

Probing DNA damage repair

Cells missing the protein HMCES are hypersensitive to DNA-damaging agents that cause a common type of DNA lesion—an "abasic" site. But the agents also generate other types of lesions associated with mutations and cell lethality, ...

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