UC San Francisco scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
Biotechnology
Jul 20, 2018
0
409
Is it better to do a task quickly and make mistakes, or to do it slowly but perfectly? When it comes to deciding how to fix breaks in DNA, cells face the same choice between two major repair pathways. The decision matters, ...
Cell & Microbiology
Sep 20, 2017
0
249
Michael Hendzel knows all too well that there is little that people can do to control the stability of their genetic code. But he hopes his latest research will help impact this elusive and crucial aspect of medicine. Published ...
Cell & Microbiology
Nov 11, 2015
3
1065
A study led by Indiana University biologist Patricia Foster and colleagues has found that forces in the external environment and oxidation are the greatest threats to an organism's ability to repair damage to its own DNA.
Cell & Microbiology
Oct 13, 2015
0
491
Dividing cells are prone to errors, and so they must be prepared to summon sophisticated emergency systems to deal with potential damage. One type of division-derailing mishap can occur when assault by certain chemicals causes ...
Cell & Microbiology
Aug 7, 2015
0
793
Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of ...
Biotechnology
Jun 4, 2015
0
17
During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication ...
Biotechnology
May 4, 2015
0
39
Genes that have roles in the same biological pathways change their rate of evolution in parallel, a finding that could be used to discover their functions, said a researcher at the University of Pittsburgh School of Medicine ...
Biotechnology
Feb 8, 2013
9
0
Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access.
Cell & Microbiology
Jun 19, 2009
0
0
A unique gene-editing method that efficiently inserts DNA into genes located in dividing and non-dividing cells of living rats has been developed by a team of international researchers, including scientists from KAUST.
Biotechnology
Jan 30, 2017
0
12
