How can human cells pack 3-meter-long DNA into their tiny nuclei and unpack it only where and when it is needed? This fascinating process is far from being completely understood.
Biotechnology
Feb 5, 2020
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The development of an adult organism starts with a fertilized egg that differentiates into hundreds of specialized cell types comprising tissues and organs. How these cell fate changes happen is a subject of research interest. ...
Cell & Microbiology
Oct 3, 2018
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Gene regulation relies on complex structural arrangements and processes at the molecular level. One of them, called 'chromatin loop extrusion', strikingly resembles the quick-lacing system of some trail running shoes: as ...
Cell & Microbiology
Dec 14, 2017
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Midlife crisis in the insect world: In a new study, Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have detected age-dependent alterations in metabolism and gene regulation in middle-aged fruitflies, and show ...
Cell & Microbiology
Jan 29, 2016
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Cells dynamically respond to environmental signals by turning appropriate sets of genes on or off. The "control system" that determines which genes need to be expressed at what time depends primarily on the interactions between ...
General Physics
Dec 4, 2015
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An LMU team has uncovered a new role for the protein Atrx, which is involved in various aspects of gene expression. The new work shows that the protein is also involved in silencing endogenous retroviral genomes integrated ...
Cell & Microbiology
May 27, 2015
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Until today, the proteins known as ubiquitin receptors have been associated mainly with protein degradation, a basic cell cleaning process. A new function now described for the protein dDsk2 by the team headed by Ferran AzorÃn, ...
Biotechnology
Apr 28, 2015
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The information encoded in our genes is translated into proteins, which ultimately mediate biological functions in an organism. Messenger RNA (mRNA) plays an important role, as it is the molecular template used for translation. ...
Biotechnology
Sep 8, 2014
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In nearly every organism's genome, scattered between genes that encode proteins, long regulatory regions stretch across expanses of DNA. Understanding what role these so-called enhancer regions play in controlling the activation ...
Biotechnology
Jul 1, 2013
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In each cell, thousands of regulatory regions control which genes are active at any time. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna have developed a method that reliably detects these regions ...
Biotechnology
Jan 18, 2013
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