How density governs receptor activation on immune cells

Scientists from within the Antibody and Vaccine Group at the University of Southampton have gained novel insights into how an important class of immune receptors called tumor necrosis factor receptors (TNFR) are activated.

How long-known genes continue to surprise researchers

The human genome was sequenced around 20 years ago. Since then, the sequence information encoding our proteins is known—at least in principle. However, this information is not continuously stored in the individual genes, ...

Receptor location in heart plays a key role in their function

In the heart there are two different subtypes of beta-adrenergic receptors—beta1 and beta2—which are activated by the stress hormones adrenaline and noradrenaline. They both trigger the strongest stimulation of the heart ...

Why moms take risks to protect their infants

It might seem like a given that mothers take extra risks to protect their children, but have you ever wondered why? A new study led by Kumi Kuroda at the RIKEN Center for Brain Science (CBS) in Japan shows that in mice, this ...

Uncovering the structure and gating mechanism of a7 protein

UT Southwestern researchers have identified the structure of a key member of a family of proteins called nicotinic acetylcholine receptors in three different shapes. The work, published online today in Cell, could eventually ...

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