The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now ...
Biochemistry
Mar 14, 2022
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348
The tumor suppressor protein p53, known as "the guardian of the genome," protects the body's DNA from daily stress or long-term damage by triggering the cells to make repairs or to self-destruct. But mutations in the p53 ...
Biochemistry
Mar 1, 2023
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31
Recent advances in imaging technology have made it possible to visualize intracellular dynamics, which offers a better understanding of several key biological principles for accelerating therapeutic development. Fluorescent ...
Biochemistry
Sep 8, 2022
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89
The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding genes - less than 2 percent of the ...
Cell & Microbiology
Apr 28, 2016
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647
Many proteins work like Swiss Army knives, fitting multiple functions into their elaborately folded structures. A bit mysteriously, some proteins manage to multitask even with structures that are unfolded and floppy—"intrinsically ...
Cell & Microbiology
Jun 19, 2013
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0
In a laboratory study pairing food chemistry and cancer biology, scientists at the Johns Hopkins Kimmel Cancer Center tested the potentially harmful effect of foods and flavorings on the DNA of cells. They found that liquid ...
Biochemistry
Mar 27, 2013
11
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Researchers have shown for the first time that the protein fortilin promotes growth of cancer cells by binding to and rendering inert protein p53, a known tumor suppressor. This finding by researchers at the University of ...
Biochemistry
Sep 16, 2011
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0
The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...
Biotechnology
Sep 7, 2011
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0
(PhysOrg.com) -- A new biophysical and biochemical study may lead to better understanding of how structural flexibility controls the interaction of a protein that is closely involved with cancer, aging and other chronic diseases ...
Biochemistry
Apr 13, 2011
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0
Like a bounty hunter returning escapees to custody, a cancer-fighting gene converts organ cells that change into highly mobile stem cells back to their original, stationary state, researchers report online at Nature Cell ...
Cell & Microbiology
Feb 25, 2011
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