New technique switches key biomolecules on and off

A new technique that will allow scientists to determine the effects of turning on and off a set of molecules involved in almost every cellular pathway, determine their downstream effects, and uncover new drug targets has ...

Crystal structure of PKG I suggests a new activation mechanism

Protein kinases, most scientists would agree, regulate nearly every aspect of cell life. It is no surprise, then, that having faulty protein kinases may lead to a number of human conditions, including cardiovascular diseases, ...

Architecture of mTOR protein complex solved

For a long time it has been known that the protein TOR - Target of Rapamycin - controls cell growth and is involved in the development of diseases such as cancer and diabetes. Researchers at the University of Basel's Biozentrum ...

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