Researchers led by Osaka University used cryogenic electron microscopy to analyze the atomic structure of the centromeric region of the chromosome, essential for cell division. A protein called CENP-A marks the centromere; ...
Cell & Microbiology
Feb 6, 2023
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73
Researchers from the University of Illinois Urbana-Champaign and the University of Illinois Chicago have demonstrated a powerful new approach to small molecule drug development.
Biochemistry
Feb 2, 2023
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21
Novel drugs, such as vaccines against COVID-19, among others, are based on drug transport using nanoparticles. Whether this drug transport is negatively influenced by an accumulation of blood proteins on the nanoparticle's ...
Bio & Medicine
Jan 20, 2023
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112
Using nanotechnology that enabled mRNA-based COVID-19 vaccines, a new approach to gene therapy may improve how physicians treat inherited forms of blindness.
Bio & Medicine
Jan 11, 2023
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21
ABC transporters constitute a major class of multidrug resistance proteins, e.g., in cancer cells. Membrane lipids have been long known to influence the structure and functional dynamics of these proteins. However, previous ...
Molecular & Computational biology
Jan 3, 2023
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3
Researchers at Rensselaer Polytechnic Institute (RPI) have published research in Molecular Pharmaceutics predicting how proteins interact in drug development. The research is a collaboration between Amgen and the University ...
Biochemistry
Nov 21, 2022
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5
Some of the toughest challenges in treating disease are presented by "undruggable" proteins whose structures and roles in disease are known but are seemingly unable to be targeted by drugs that will bind to them. Researchers ...
Molecular & Computational biology
Nov 21, 2022
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33
A new study led by ISGlobal and IGTP uses a mouse model with human liver cells to characterize proteins associated with the latent form of the malaria parasite Plasmodium vivax. The findings lay the groundwork for identifying ...
Cell & Microbiology
Nov 8, 2022
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3
The latest developmental drugs, particularly for use in oncology, rely on the targeted degradation of harmful pathogenic proteins. In a recent study published in Nature Chemical Biology, researchers at CeMM, the Research ...
Biochemistry
Nov 3, 2022
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32
The medical profession is in the midst of losing an arms race. Bacterial antibiotic resistance doesn't just threaten our ability to treat infection but our ability to carry out any treatment where infection is a risk. This ...
Cell & Microbiology
Oct 31, 2022
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