How the influenza virus achieves efficient viral RNA replication

New insights on how subunits of the influenza virus polymerase co-evolve to ensure efficient viral RNA replication are provided by a study published October 3 in the open-access journal PLOS Pathogens by Nadia Naffakh of ...

New DNA amplification capsule holds promise for fighting diseases

DNA amplification—a molecular "photocopying" technique where genetic material is replicated—has many applications in scientific research, forensic science, and medical laboratories. It is useful for detecting and identifying ...

Histone modifications are the influencers of zygotic genome awakening

The zebrafish is an important model organism in biology. Humans and zebrafish share 70 percent of their genes, and more than 80 percent of human genes associated with disease are known to have a zebrafish counterpart. Additionally, ...

Polymerase

A polymerase (EC 2.7.7.6/7/19/48/49) is an enzyme whose central function is associated with polymers of nucleic acids such as RNA and DNA. The primary function of a polymerase is the polymerization of new DNA or RNA against an existing DNA or RNA template in the processes of replication and transcription. In association with a cluster of other enzymes and proteins, they take nucleotides from solvent, and catalyse the synthesis of a polynucleotide sequence against a nucleotide template strand using base-pairing interactions.

It is an accident of history that the enzymes responsible for the catalytic production of other biopolymers are not also referred to as polymerases.

One particular polymerase, from the thermophilic bacterium, Thermus aquaticus (Taq) (PDB 1BGX, EC 2.7.7.7) is of vital commercial importance due to its use in the polymerase chain reaction, a widely used technique of molecular biology.

Other well-known polymerases include:

This text uses material from Wikipedia, licensed under CC BY-SA