New approach makes it easier to find novel drugs
Scientists have created a new way of screening compounds that is more sensitive than existing methods, opening up the possibility of finding new drugs for many diseases.
Scientists have created a new way of screening compounds that is more sensitive than existing methods, opening up the possibility of finding new drugs for many diseases.
Biochemistry
Aug 7, 2017
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141
Scientists at UC San Francisco have found a more precise way to turn off genes, a finding that will speed research discoveries and biotech advances and may eventually prove useful in reprogramming cells to regenerate organs ...
Biotechnology
Mar 7, 2013
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A team of Spanish researchers, coordinated by the Spanish National Research Council (CSIC), has started to sequence the genome of the global deep ocean. They are using more than 2,000 samples of microorganisms collected in ...
Biotechnology
Jun 12, 2013
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Pancreatic cancer is an exceedingly malignant tumor in the digestive system, and its five-year survival rate is little more than 10%. Metabolic alterations are one of the hallmarks of tumor cells. Oncogenic Kras-activated ...
Biochemistry
Aug 19, 2022
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82
Enzymes called protein kinases modulate cellular activities in virtually every organism. They switch other proteins off or on by tacking on phosphate chemical groups—a process known as phosphorylation—to regulate the ...
Cell & Microbiology
Aug 2, 2013
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Circadian rhythms keep time for all living things, from regulating when plants open their flowers to foiling people when they try to beat jet lag. Day-night cycles are controlled through ancient biological mechanisms, evolutionarily ...
Cell & Microbiology
Apr 11, 2013
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(Phys.org)—A new way to visualize single-cell activity in living zebrafish embryos has allowed scientists to clarify how cells line up in the right place at the right time to receive signals about the next phase of their ...
Cell & Microbiology
Nov 13, 2012
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When harmful insects attack a plant, it defends itself. It forms protective substances that are poisonous for the insects. This defense response is activated by messengers, jasmonates. Their biosynthesis had been deemed to ...
Biotechnology
Jan 12, 2018
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18
Whitehead Institute scientists have determined how to use alpaca-derived, single-domain antibody fragments (also called VHHs or nanobodies) to perturb cellular processes in mammalian cells, including the infection of human ...
Cell & Microbiology
Jun 20, 2016
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6
Plants are impressive in their diversity, but especially in the variety of metabolites they produce. Many plant natural products are highly complex molecules, such as the alkaloids vincristine and vinblastine, which are produced ...
Biochemistry
May 15, 2023
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8