Scientists unlock key to cancer cell death mystery
An international team of scientists has announced a new advance in the ability to target and destroy certain cancer cells.
Biochemistry
Mar 26, 2012
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0
News tagged with p53
Cancer biologists find DNA-damaging toxins in common plant-based foods
In a laboratory study pairing food chemistry and cancer biology, scientists at the Johns Hopkins Kimmel Cancer Center tested the potentially harmful effect of foods and flavorings on the DNA of cells. They found that liquid ...
Biochemistry
Mar 27, 2013
11
0
A long-noncoding RNA regulates repair of DNA breaks in triple-negative breast cancer cells
The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding genes - less than 2 percent of the ...
Cell & Microbiology
Apr 28, 2016
0
647
Stem cells are wired for cooperation, down to the DNA
We often think of human cells as tiny computers that perform assigned tasks, where disease is a result of a malfunction. But in the current issue of Science, researchers at The Mount Sinai Medical Center offer a radical view ...
Biotechnology
Sep 12, 2013
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0
How spider silk could one day be used in cancer treatment
Cancer is simultaneously one of the most common and devastating diseases in our society. So working out new ways to treat it is an enduring scientific challenge.
Biochemistry
Mar 17, 2022
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57
Scientists discover compound which targets cancer cells that lack the protective p53 'guardian gene'
A new chemical compound with the potential to destroy hard-to-treat cancer cells has been developed and tested by scientists at the University of Huddersfield.
Biochemistry
Aug 15, 2018
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194
Cancer is a p53 protein aggregation disease
Protein aggregation, generally associated with Alzheimer's and mad cow disease, turns out to play a significant role in cancer. In a paper published in Nature Chemical Biology, Frederic Rousseau and Joost Schymkowitz of VIB, ...
Biochemistry
Mar 29, 2011
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1
Guarding the genome: Researchers uncover full 3D structure of p53 protein
The tumor suppressor protein p53, known as "the guardian of the genome," protects the body's DNA from daily stress or long-term damage by triggering the cells to make repairs or to self-destruct. But mutations in the p53 ...
Biochemistry
Mar 1, 2023
0
31
Why chemotherapy causes more infertility in women than in men
For a long time a relationship between infertility and chemotherapeutic agents has been assumed. Now, the mechanism has been elucidated. Mainly women are affected because the quality control in the oocytes is different from ...
Biochemistry
Feb 22, 2011
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0
Novel compound selectively kills cancer cells
A cancer cell may seem out of control, growing wildly and breaking all the rules of orderly cell life and death. But amid the seeming chaos there is a balance between a cancer cell's revved-up metabolism and skyrocketing ...
Biochemistry
Jul 13, 2011
1
0
P53
More reference expression data
p53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome," "the guardian angel gene," and the "master watchman," referring to its role in conserving stability by preventing genome mutation.
The name p53 is in reference to its apparent molecular mass: it runs as a 53 kilodalton (kDa) protein on SDS-PAGE. But based on calculations from its amino acid residues, p53's mass is actually only 43.7kDa. This difference is due to the high number of proline residues in the protein which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish.
This text uses material from Wikipedia, licensed under CC BY-SA
