Related topics: cancer cells

A chaperone for the 'guardian of the genome'

The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...

Cancer is a p53 protein aggregation disease

Protein aggregation, generally associated with Alzheimer's and mad cow disease, turns out to play a significant role in cancer. In a paper published in Nature Chemical Biology, Frederic Rousseau and Joost Schymkowitz of VIB, ...

Protein and microRNA block cellular transition vital to metastasis

Like a bounty hunter returning escapees to custody, a cancer-fighting gene converts organ cells that change into highly mobile stem cells back to their original, stationary state, researchers report online at Nature Cell ...

Why chemotherapy causes more infertility in women than in men

For a long time a relationship between infertility and chemotherapeutic agents has been assumed. Now, the mechanism has been elucidated. Mainly women are affected because the quality control in the oocytes is different from ...

Eggs' quality control mechanism explained

To protect the health of future generations, body keeps a careful watch on its precious and limited supply of eggs. That's done through a key quality control process in oocytes (the immature eggs), which ensures elimination ...

p53 determines organ size

In studies conducted on the fruit fly, researchers at IRB Barcelona (Spain) headed by ICREA Professor Marco Milan have revealed that organs have the molecular mechanisms to control their proportions. In this process the protein ...

Advances reported in quest for drugs targeting childhood cancer

Investigators believe they have identified the founding member of a chemical family they hope will lead to a new class of cancer drugs, the first designed specifically against a childhood tumor, according to research led ...

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