New 3-D cultured cells mimic the progress of NASH

A research team led by scientists from Tokyo University of Agriculture and Technology (TUAT), Japan, has successfully established 3-D cultured tissue that mimics liver fibrosis, a key characteristic of non-alcoholic steatohepatitis ...

CRISPR-HOT: A new tool to 'color' specific genes and cells

Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs. They used this new method, called CRISPR-HOT, to investigate ...

Snake stem cells used to create venom-producing organoids

Organoids have become an important tool for studying many disease processes and testing potential drugs. Now, they are being used in a surprising and unexpected way: for the production of snake venom. On January 23 in the ...

Researchers decode the circuitry of neuromuscular organoids

The Gouti lab from the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) has developed functional neuromuscular organoids (NMOs) that self-organize into spinal cord neurons and muscle tissue. ...

Gut feeling: A network approach towards understanding IBD

Diseases of the gut are often notoriously difficult to diagnose, nevermind understand, which is where a network-based approach comes in. Rather than trying to understand individual symptoms, or the role of individual genes, ...

How human brain development diverged from great apes

Researchers from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, Institute of Molecular and Clinical Ophthalmology Basel, and ETH Zurich, Switzerland, have presented new insights into the development ...

Growing a smarter model for brain research in space

Researchers studying neurological diseases face several daunting challenges. For one thing, these conditions may take years or even decades to develop. On top of that, experimenting on the brains of healthy human beings simply ...

Brain waves detected in mini-brains grown in a dish

Scientists have created miniature brains from stem cells that developed functional neural networks. Despite being a million times smaller than human brains, these lab-grown brains are the first observed to produce brain waves ...

Cyborg organoids offer rare view into early stages of development

What happens in the early days of organ development? How do a small group of cells organize to become a heart, a brain, or a kidney? This critical period of development has long remained the black box of developmental biology, ...

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