Nuclear pore complex outer rings: No longer 'one size fits all'

In eukaryotic cells, the nucleus is walled off from the rest of the cell by the nuclear envelope. All transport into and out of the nucleus occurs via cylindrical channels called nuclear pore complexes (NPCs) that penetrate ...

How HIV DNA is blocked from entering the cell nucleus

Multiple components of the nuclear pore complex and nuclear import machinery enable a protein called human myxovirus resistance 2 (MX2) to inhibit HIV-1 infection, according to a study published November 29 in the open-access ...

Scientists map the portal to the cell's nucleus

Like an island nation, the nucleus of a cell has a transportation problem. Evolution has enclosed it with a double membrane, the nuclear envelope, which protects DNA but also cuts it off from the rest of the cell. Nature's ...

Nuclear pore complex successfully mapped and diagramed

(Phys.org)—Two teams of researchers taking different approaches have successfully mapped and diagramed the nuclear pore complex (NPC)—protein complexes that make up the pores in the nuclear envelope that allow or prevent ...

How packing away DNA stabilizes cell fate decisions

Susan Gasser and her group at the FMI have identified in C. elegans a much sought-for anchor protein, a previously uncharacterized chromodomain protein called CEC-4 that directly sequesters inactive chromatin at the nuclear ...

DNA strands often 'wiggle' as part of genetic repair

Sometimes, the molecules that make up life exhibit strange behavior. For instance, in simple organisms such as yeast, when genetic material becomes damaged, the affected DNA strands increase their motion, waving about inside ...

Chemists solve major piece of cellular mystery

Not just anything is allowed to enter the nucleus, the heart of eukaryotic cells where, among other things, genetic information is stored. A double membrane, called the nuclear envelope, serves as a wall, protecting the contents ...

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