Curing genetic disease in human cells

While the genome editing tool CRISPR/Cas9, developed in 2012, cuts a mutation out of a gene and replaces it with a gene-piece, a newer type of CRISPR, called base-editing, can repair a mutation without cutting the DNA. Therefore, ...

Mathematical model reveals behavior of cellular enzymes

Everything a cell does, from dividing in two to migrating to a different part of the body, is controlled by enzymes that chemically modify other proteins in the cell. Researchers at Princeton University have devised a new ...

Human language most likely evolved gradually

One of the most controversial hypotheses for the origin of the human language faculty is the evolutionary conjecture that language arose instantaneously in humans through a single gene mutation. `

Local genetic adaption helps sorghum crop hide from witchweed

Sorghum crops in areas where the agricultural parasite striga, also known as witchweed, is common are more likely to have genetic adaptations to help them resist the parasite, according to new research led by Penn State scientists. ...

Building better base editors

CRISPR-based gene editing has potential therapeutic benefits but also some technical shortcomings. One set of these gene editing tools, base editors, can rewrite the four individual DNA letters, or bases— A, C, T or G—which ...

Faster drug discovery to hit 'undruggable' targets

Medicines made from coiled protein fragments could provide a new handle on hard-to-treat diseases like cancer, but they are difficult to design. But a new technique, developed at the University of Michigan, could change that.

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