CRISPR-Cas9 can generate unexpected, heritable mutations

CRISPR-Cas9, the "genetic scissors," creates new potential for curing diseases, but treatments must be reliable. In a new study, researchers have discovered that the method can give rise to unforeseen changes in DNA that ...

Gene mutation that makes dogs small existed in ancient wolves

Popular belief has been that small dogs, such as Pomeranians and Chihuahuas, exist because once dogs were domesticated, humans wanted small, cute companions. But in the journal Current Biology on January 27, researchers at ...

Comprehensive detection of on- and off-target mutations

Sometimes the smallest action can have unintended consequences, like the proverbial flap of a butterfly's wings. So, when making small changes, it's important to be alert to large effects, such as when using gene editing ...

New spheres of knowledge on the origin of life

The shape of a cell affects its physical and chemical properties. Different cell types have developed different shapes to enable effective functioning. But what shape were the very first cells, as life began to evolve?

Developing tools to visualize DNA repair as never before

Each one of the trillions of cells that make up the human body suffers more than 10,000 DNA lesions every day. These injuries would be catastrophic if cells were unable to repair them, but a very delicate machinery that detects ...

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