BBS proteins shown to run an export business that protects cilia

A protein complex mutated in human disease removes excess signaling molecules to prevent them from damaging cilia, say researchers from UMass Medical School. The study will be published in the December 28 issue of the Journal ...

How key genes cooperate to make healthy skin

Skin is the body's armor, protecting us from disease agents, injury, excessive water loss, and cold and heat. Yet mutations in a single gene, the gene for the protein p63, cause numerous diseases and malformations of the ...

Fly study finds two new drivers of RNA editing

RNA editing gives organisms a way to adapt the instructions that their DNA provides for making proteins. Few people would have described RNA editing as a simple process, but a new paper in Nature Communications demonstrates ...

Physics explains protein unpredictability

University of Oregon scientists theorized that they could manipulate a protein one mutation at a time and predict its evolution. They sought to prove it. And failed.

Proteins use a lock and key system to bind to DNA

You can think of DNA as a string of letters—As, Cs, Ts, and Gs—that together spell out the information needed for the construction and function of cells. Each cell in your body shares the same DNA. So, for cells to take ...

Study finds 'silent' genetic variations can alter protein folding

Proteins, the workhorse of the human cell, help digest our food, carry oxygen through the body, fight off invading microbes, and so much more—but they only function when folded properly into specific, three dimensional ...

Bioinformaticians examine new genes the moment they are born

Accumulating evidence suggests that new genes can arise spontaneously from previously non-coding DNA instead of through the gradual mutation of established genes. Bioinformaticians at the University of Münster (Germany) ...

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