New technology selects high-affinity proteins

Kobe University and the National Institute of Advanced Industrial Science and Technology (AIST) in Japan have developed a technology enabling the selection of proteins with a high affinity for drug target molecules (also ...

Researchers unveil DNA-guided 3-D printing of human tissue

A UCSF-led team has developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks. These ...

M6P deficiency leaves B cells out of sorts

A group of white blood cells known as B cells, which play a key role in the human immune response, need a protein-targeting signal called mannose 6-phosphate (M6P) in order to proliferate, differentiate, and present immune ...

Histones and the mystery of cell proliferation

Before cells divide, they create so much genetic material that it must be wound onto spools before the two new cells can split apart. These spools are actually proteins called histones, and they must multiply at the same ...

Negative feedback makes cells 'sensitive'

New research has shown that negative feedback loops in cell signalling systems can be essential for a cell's ability to perceive the strength of a growth stimulus. Cells lacking the feedback loop became insensitive to the ...

Mitochondrial cooperatives

Mitochondria, the organelles that supply the cell with energy, are highly dynamic and can link up to form complex tubular networks. A new study shows that this response can transiently compensate for a shortfall in energy ...

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