New cyclization reactions for synthesizing macrocyclic drug leads

Scientists at EPFL have developed a new method to synthesize and screen thousands of macrocyclic compounds, a family of chemicals that are of great interest in the pharmaceutical industry. The study is published in Science ...

Using 'counterfactuals' to verify predictions of drug safety

Scientists rely increasingly on models trained with machine learning to provide solutions to complex problems. But how do we know the solutions are trustworthy when the complex algorithms the models use are not easily interrogated ...

Soft drink could enhance effects of an anti-cancer drug

Experiments with an artificial stomach suggest that a popular lemon-lime soft drink could play an unexpected role in improving the effectiveness of an oral anticancer drug. The experiments produced evidence that patients ...

A realistic look at the promises and perils of nanomedicine

Is the emerging field of nanomedicine a breathtaking technological revolution that promises remarkable new ways of diagnosing and treating diseases? Or does it portend the release of dangerous nanoparticles, nanorobots or ...

Hitching a ride: Misfiring drugs hit the wrong targets

It probably isn't surprising to read that pharmaceutical drugs don't always do what they're supposed to. Adverse side effects are a well-known phenomenon and something many of us will have experienced when taking medicines.

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