The endoplasmic reticulum (ER) is a major organelle responsible for protein folding and trafficking. Protein folding stress in the ER can lead to the accumulation of unfolded or misfolded proteins, known as ER stress, which ...
Cell & Microbiology
Jun 25, 2024
0
18
By converting their data into sounds, scientists discovered how hydrogen bonds contribute to the lightning-fast gyrations that transform a string of amino acids into a functional, folded protein.
Biochemistry
May 20, 2024
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46
Proteins are like tiny machines in our bodies, helping with almost everything we do, including breaking down food, carrying messages between cells, and building and repairing tissues, like muscles and skin.
Molecular & Computational biology
May 16, 2024
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1
Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and ...
Cell & Microbiology
Jan 4, 2024
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31
A team of chemists, microbiologists and physicists at the University of Cambridge in the U.K. has developed a way to use solid-state nanopores and multiplexed DNA barcoding to identify misfolded proteins such as those involved ...
As life propagated across Earth in the form of the widest variety of single-celled organisms, sometime between 3.5 and 1 billion years ago one such organism managed an evolutionary coup: Instead of devouring and digesting ...
Cell & Microbiology
Jul 28, 2023
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35
Misfolded proteins are toxic to cells. They disrupt normal functions and cause some age-related human degenerative diseases, like Alzheimer's, Parkinson's, and Huntington's diseases. Cells work constantly to eliminate misfolded ...
Cell & Microbiology
Apr 20, 2023
0
121
In humanity's ongoing quest for the elixir of life, the science keeps pointing to stem cells. Research increasingly shows that maintaining stem cell fitness promotes a long healthspan, and new findings show keeping stem cells ...
Cell & Microbiology
Mar 21, 2023
0
78
Published in the Molecular Cell journal on July 19, a research study out of the Hatters Laboratory showed inappropriate protein aggregation is linked to poor outcomes for cell health and survival—especially in neurons in ...
Cell & Microbiology
Jul 19, 2022
0
16
FMI researchers developed an imaging approach that allowed them to visualize individual molecules involved in the cell's response to stress.
Cell & Microbiology
Jun 29, 2022
0
16
