Recent studies showing acid ceramidase (AC) to be upregulated in melanoma, lung and prostate cancers have made the enzyme a desired target for novel synthetic inhibitor compounds. This week in Angewandte Chemie, a top journal ...
Biochemistry
Nov 20, 2014
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Using a simple glass capillary, atomic physicists at RIKEN are developing an ultra-narrow ion beam that pinpoints a part of organelles in a living cell, enabling biologists to visualize how the damage affects cell activities.
General Physics
Apr 4, 2011
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A "game-changing" technique using near infrared light enables scientists to look deeper into the guts of cells, potentially opening up a new frontier in the fights against cancer and many other diseases.
Biochemistry
Sep 1, 2010
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Using a chemical trick that allows them to change the acidity of a solution almost instantly, a team at the National Institute of Standards and Technology has demonstrated a simple and effective technique for quantifying ...
Materials Science
Jun 9, 2010
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The kinase IKK phosphorylates the protein mutated in Huntington's disease to promote its removal and neuron survival, but IKK may be a double-edged sword that increases neurotoxicity in later stages of the disease. The study, ...
Cell & Microbiology
Dec 21, 2009
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Tsuruta et al. find that a lipid kinase directs a voltage-gated calcium channel's degradation to save neurons from a lethal dose of overexcitement. The study appears in the October 19, 2009 issue of the Journal of Cell Biology ...
Cell & Microbiology
Oct 19, 2009
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Lysosomes are critical for cellular degradation, characterized by their acidic pH and array of hydrolytic enzymes. They degrade materials through endocytosis, phagocytosis, and autophagy, recycling essential components. Lysosomes ...
Cell & Microbiology
May 8, 2024
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A team from the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona (UB), in collaboration with a researcher from the Mayo Clinic and the University of Minnesota, have described that lysosomes ...
Cell & Microbiology
Jul 7, 2020
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