116 scientists reject WHO's draft PFAS guidelines

More than 100 scientists sent a letter to the World Health Organization today urging a complete overhaul or withdrawal of the organization's draft drinking water guidelines for the two most well-studied per- and polyfluoroalkyl ...

Toxic 'forever chemicals' accumulate above the water table

PFAS (per- and polyfluoroalkyl substances) are water-, stain-, and heat-resistant chemicals added to products like nonstick pans, nail polish, food wrappers, and firefighting foam. They have been linked to health problems, ...

Pet food recall expands after 70 dogs die from mold toxin

There's an expanded nationwide recall of Sportmix pet food products underway, after links were found between a mold-borne toxin in the food and the deaths of 70 dogs, with 80 other dogs being sickened, the U.S. Food and Drug ...

One drug, many diseases

It seems too good to be true: a single drug that could treat humanity's worst afflictions, including atherosclerosis, cancer, Alzheimer's, Parkinson's and arthritis. All of these diseases have one thing in common—they involve ...

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Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the organ. Other chemical agents such as those used in laboratories and industries, natural chemicals (e.g. microcystins) and herbal remedies can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins.

More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Chemicals often cause subclinical injury to liver which manifests only as abnormal liver enzyme tests. Drug induced liver injury is responsible for 5% of all hospital admissions and 50% of all acute liver failures.

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