Malaria could be felled by an Antarctic sea sponge

The frigid waters of the Antarctic may yield a treatment for a deadly disease that affects populations in some of the hottest places on earth. Current medications for that scourge—malaria—are becoming less effective as ...

Malaria hijacks your genes to invade your liver

In the search for new weapons against malaria, most drug development has focused on the parasites that cause the disease. But Duke University researchers are trying a different tack. Instead of targeting the malaria parasite ...

Early in vitro testing for adverse effects on embryos

ETH researchers have combined embryonic cells and liver cells in a new cell culture test. This combination lets them detect adverse effects that new medications may have on embryos early on in the drug development process.

New progress in developing an animal model of hepatitis C

Small differences in a liver cell protein have significant impacts on hepatitis C virus replication in mice and humans, findings that could facilitate the development of a mouse model of the infection. The report, led by ...

3-D culturing hepatocytes on a liver-on-a-chip device

Liver-on-a-chip cell culture devices are attractive biomimetic models in drug discovery, toxicology and tissue engineering research. To maintain specific liver cell functions on a chip in the lab, adequate cell types and ...

A molecular look at nascent HDL formation

Oil and water don't mix. But our aqueous blood is full of different types of hydrophobic lipids—including cholesterol. In order to travel via the bloodstream, those lipids need to hitch a ride on an amphipathic carrier. ...

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