New potential target proteins for novel antibiotics discovered

Bacteria are small but tough organisms, partly because their cells are enclosed by a protective cell wall skeleton. Professor Felipe Cava and his team at UmeƄ University in Sweden and collaborators at Harvard Medical School ...

Pacemaker channel discovery could lead to better heart drugs

The mechanism by which fat-related molecules called lipids regulate pacemaker ion channel proteins, which help control the heart rhythm, has been revealed in a study from researchers at Weill Cornell Medicine.

Bacterial armor plating has implications for antibiotics

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armor, which has far-reaching implications for the development of ...

New understanding of the inner world of lysosomes

Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown factories of cells. The findings, ...

'Youngest' antibiotic kills bacteria via a new two-step mechanism

Scientists at Utrecht University have discovered a new mechanism antibiotics use to kill bacteria. The antibiotic teixobactin uses a dual molecular strategy: it blocks the bacterial cell wall synthesis and destructs the cell ...

Breakthrough in study of how epithelial cells become cancerous

Epithelial cells, which line the surfaces and organs of the body, can protect themselves against cancer by removing unhealthy or abnormal cells through a mechanism known as "apical extrusion," where the damaged cells are ...

Newly discovered lipid prevents cell death

Programmed cell death is an important tool that an organism uses to keep itself healthy. When a cell does not function as it should, various stress reactions are activated. The goal of these reactions is to restore the original ...

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