New potential target proteins for novel antibiotics discovered

Bacteria are small but tough organisms, partly because their cells are enclosed by a protective cell wall skeleton. Professor Felipe Cava and his team at Umeå University in Sweden and collaborators at Harvard Medical School ...

Pacemaker channel discovery could lead to better heart drugs

The mechanism by which fat-related molecules called lipids regulate pacemaker ion channel proteins, which help control the heart rhythm, has been revealed in a study from researchers at Weill Cornell Medicine.

Bacterial armor plating has implications for antibiotics

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armor, which has far-reaching implications for the development of ...

Embedding iron oxide into liposome bilayer to trigger ferroptosis

Ferroptosis, an iron-dependent regulated cell death process driven by excessive lipid peroxides and membrane injury, can enhance cancer vulnerability to chemotherapy. Lipid peroxidation of unsaturated lipids (UL) in biological ...

New understanding of the inner world of lysosomes

Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown factories of cells. The findings, ...

Discovery of protein that regulates plant cell wall mechanics

Glycosylphosphatidylinositol (GPI) anchoring is an important post-translational modification, which tethers non-transmembrane proteins to the outer leaflet of the plasma membrane (PM). It participates in many biological processes ...

'Youngest' antibiotic kills bacteria via a new two-step mechanism

Scientists at Utrecht University have discovered a new mechanism antibiotics use to kill bacteria. The antibiotic teixobactin uses a dual molecular strategy: it blocks the bacterial cell wall synthesis and destructs the cell ...

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