80-year-old antibiotic redesigned for new medical uses

Physicians and scientists have long searched the natural world for chemicals that can improve human health. However, evolutionary selection optimized natural chemicals to benefit their host, not for safety or efficacy in ...

Hook-on drugs: New delivery strategy for K-Ras disruption

"The strategy was to design the drug to be able to hook into the hole of the FTase and GGTase I, otherwise the surface of the proteins are too large and slippery," Dr. Junko Ohkanda of Shinshu University explains her strategy ...

New polymer mesophase structure discovered

Polymers, large molecules made up of repeating smaller molecules called monomers, are found in nearly everything we use in our day-to-day lives. Polymers can be natural or created synthetically. Natural polymers, also called ...

Closing the gap: A two-tier mechanism for epithelial barrier

Scientists from Japan's National Institute for Physiological Sciences and their collaborators report in a new study published in the Journal of Cell Biology that the epithelial barrier is composed of two molecular systems ...

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