A team led by Prof. Dr. Han Sun from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has elucidated an important mechanism in the function of TREK channels at an atomic level. The results, published in ...
Molecular & Computational biology
Jul 10, 2024
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5
Several million cells divide every second in our bodies. During nuclear division (mitosis), the genetic material must be distributed correctly and completely between the daughter cells—errors in this process can lead to ...
Cell & Microbiology
Jun 4, 2024
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10
Enhancing drug development for life-threatening diseases like cancer hinges on a deep understanding of protein kinases, making it a focal point for researchers. These enzymes, encoded by more than 500 human genes, serve as ...
Biochemistry
May 24, 2024
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52
In the human body, molecules known as kinases propagate signals within and between cells, relaying signals that allow cells to respond to changes in the environment. However, there are hundreds of different kinases in the ...
Biochemistry
May 8, 2024
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130
When pathogens attack plants, the plant cells almost immediately react. The plant's cells begin to produce different kinds of small molecules called secondary messengers. These messengers travel throughout the cell membrane ...
Plants & Animals
Feb 26, 2024
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1
Norwegian University of Science and Technology (NTNU) researchers have developed a promising antibiotic candidate against MRSA. Behind the discovery lies a methodology that may be important in the fight against antimicrobial ...
Cell & Microbiology
Dec 15, 2023
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36
Protein phosphorylation is a major posttranslational modification carried out by protein kinases that constitute an integral part of complex signaling networks in eukaryotes. Casein kinase 1 (CK1) is a conserved serine/threonine ...
Plants & Animals
Sep 28, 2023
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19
Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism's normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response.
Molecular & Computational biology
Sep 14, 2023
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142
Signal transduction and perception regulates biological activities to adapt to changing environments. The Pert-Arnt-Sim domains are commonly available sensors found across diverse receptors in bacteria, eukaryotes, and archaea. ...
Synthetic biologists from Rice University and Princeton University have demonstrated "live reporter" technology that can reveal the workings of networks of signaling proteins in living cells with far greater precision than ...
Cell & Microbiology
Jul 10, 2023
0
589
In chemistry and biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. Kinases are part of the larger family of phosphotransferases. Kinases are not to be confused with phosphorylases, which carry out phosphorolysis, the breaking of a bond using an inorganic phosphate group; or with phosphatases, which remove phosphate groups.
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