Age-related stem cell dysfunction linked to eye-color gene

In a discovery with implications for colorectal cancer in humans, RIKEN geneticists have found that a gene that determines eye color in fruit flies also plays a role in the tendency of gut stem cells to proliferate out of ...

Intestinal regeneration: Lessons from organoid research

The last decade has seen a boom in the field of organoids, miniature organs grown from stem cells in vitro. These systems recapitulate the cell type composition and numerous functions of parent organs—such as brain, kidney, ...

A new molecular guardian of intestinal stem cells

Intestinal stem cells hold a fine balance between two potential forms: remaining as stem cells, or developing into intestinal epithelial cells. In a new study, researchers from Tokyo Medical and Dental University (TMDU) discovered ...

Intestines modify their cellular structure in response to diet

Body organs such as the intestine and ovaries undergo structural changes in response to dietary nutrients that can have lasting impacts on metabolism, as well as cancer susceptibility, according to Carnegie's Rebecca Obniski, ...

How intestinal cells renew themselves

The intestine must be able to renew itself to recover from environmental insults like bacterial infections. This renewal is made possible by a small number of intestinal stem cells which divide and produce daughter cells ...

It's all about the (stem cell) neighborhood

Stem cells have the ability to develop, or differentiate, into the many cell types in the body. They also serve as a repair system to replace aged or damaged cells. With their regenerative abilities, stem cells offer enormous ...

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