From droplet to discovery

Stem cells overflow with potential. Their ability to become other cell types is crucial to our bodies, both during development and throughout life. But this potential can be our very downfall if it goes wrong, turning some ...

How intestine replaces and repairs itself

To act as a robust barrier against pathogens while also absorbing needed nutrients, the lining of the intestines must regenerate on a daily basis to remain equal to the task. The intestine's resident stem cells are responsible ...

Age-related stem cell dysfunction linked to eye-color gene

In a discovery with implications for colorectal cancer in humans, RIKEN geneticists have found that a gene that determines eye color in fruit flies also plays a role in the tendency of gut stem cells to proliferate out of ...

Intestinal regeneration: Lessons from organoid research

The last decade has seen a boom in the field of organoids, miniature organs grown from stem cells in vitro. These systems recapitulate the cell type composition and numerous functions of parent organs—such as brain, kidney, ...

A new molecular guardian of intestinal stem cells

Intestinal stem cells hold a fine balance between two potential forms: remaining as stem cells, or developing into intestinal epithelial cells. In a new study, researchers from Tokyo Medical and Dental University (TMDU) discovered ...

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