How the insulin receptor works

As we are approaching the 100th anniversary of the discovery of insulin, a wide array of its signaling pathways has been defined. However, the initial step in insulin action, i.e. the engagement with its cell-surface receptor ...

Chemically modified insulin is available more quickly

Replacing a hydrogen atom by an iodine atom in insulin, the hormone retains its efficacy but is available more rapidly to the organism. Researchers at the University of Basel were able to predict this effect based on computer ...

Protective hinge process enables insulin to bind to cells

Since its landmark discovery in 1922, insulin has improved the health and extended the lives of more than 500 million people worldwide with diabetes mellitus. Yet the question of how this key hormone binds to its target cells ...

Battles between steroid receptors to regulate fat accumulation

The androgen receptor in human cells inhibits fat accumulation, but its activity can be sabotaged by glucocorticoids, steroids that regulate fat deposition and are known drivers of obesity and insulin resistance, said researchers ...

Red wine, fruit compound could help block fat cell formation

(PhysOrg.com) -- A compound found in red wine, grapes and other fruits, and similar in structure to resveratrol, is able to block cellular processes that allow fat cells to develop, opening a door to a potential method to ...

Mice with fewer insulin-signaling receptors don't live longer

Scientists studying longevity thought it might be good to lack a copy of a gene, called IGF1 receptor, that is important in insulin signaling. Previous studies showed invertebrates that lacked the copy lived longer, even ...

Protein love triangle key to crowning bees queens?

A honey bee becomes a royal queen or a common worker as a result of the food she receives as a larva. While it has been well established that royal jelly is the diet that makes bees queens, the molecular path from food to ...

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