Landing therapeutic genes safely in the human genome

Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called "genomic safe harbors (GSHs)." These are ...

Cilia-free stem cells offer new path to study rare diseases

A group of rare diseases called "ciliopathies"—polycystic kidney disease notable among them—emerge from defects in cilia, the tiny hair-like structures on the surface of almost every cell type. But the specific molecular-level ...

Passing on the right antibodies: Protecting piglets from diarrhea

The parasite Cystoisospora suis affects suckling pigs causing severe intestinal problems, such as diarrhoea. Scientists at the University of Veterinary Medicine, Vienna (Vetmeduni) have now shown that antibodies against Cystoisospora ...

Learning the alphabet of gene control

Scientists at Karolinska Institutet in Sweden have made a large step towards the understanding of how human genes are regulated. In a new study, published in the journal Cell, they identified the DNA sequences that bind to ...

New method captures early viral-host protein interactions

More than 70% of all viruses known to cause human disease, including the one that causes COVID-19, are RNA viruses. They invade the body by hijacking the internal machinery of cells. Yet little is known about how viral RNA ...

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