Local modifications in histone proteins alter DNA packing density in the cell nucleus to regulate gene activity. They also form the basis of a code in which the significance of a given pattern or motif depends on its broader ...
Biotechnology
Jan 28, 2016
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Humans may inevitably explore other planets, moons, and asteroids within our solar system. And although life on Earth has adapted to our planet's gravitational field, this looming possibility begs the question: How will animals ...
Cell & Microbiology
Feb 10, 2015
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The packaging of a gene has a major impact on its functional state and must be precisely controlled. A novel blend of methods has unveiled the architecture of a large protein complex that modulates DNA packing, and hints ...
Cell & Microbiology
Sep 16, 2013
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Researchers at the IMP Vienna discovered that cohesin stabilizes DNA. Jan-Michael Peters and his team at the Research Institute of Molecular Pathology (IMP) found that the structure of Chromosomes is supported by a kind of ...
Cell & Microbiology
Aug 26, 2013
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The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism that allows chromosomal ...
Biochemistry
May 23, 2013
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Every gene in the nucleus of an animal or plant cell is packaged into a beads-on-a-string like structure called nucleosomes: the DNA of the gene forms the string and a complex of proteins called histones forms the beads around ...
Biotechnology
Feb 11, 2013
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Within all our cells lies two meters of DNA, highly ordered in a structure of less than 10 micro meters in diameter. Special proteins called histones act as small building bricks, organising our DNA in this structure. Preservation ...
Cell & Microbiology
Mar 12, 2012
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Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they ...
Biochemistry
Mar 1, 2012
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Researchers at RIKEN have uncovered a mechanism by which the effects of stress in the fly species Drosophila are inherited epigenetically over many generations through changes to the structure of chromatin, the material that ...
Cell & Microbiology
Jun 23, 2011
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The genetic inherited material DNA was long viewed as the sole bearer of hereditary information. The function of its packaging proteins, the histones, was believed to be exclusively structural. Additional genetic information ...
Biotechnology
Oct 11, 2010
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