Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA ...
Cell & Microbiology
Jun 6, 2024
0
8
UCLA scientists have identified a protein that plays a critical role in regulating human blood stem cell self-renewal by helping them sense and interpret signals from their environment.
Cell & Microbiology
Jun 5, 2024
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40
As people age, they become more prone to blood clotting diseases, when blood cells called platelets clump together when they don't need to and can cause major issues such as strokes and cardiovascular disease. For decades, ...
Cell & Microbiology
May 14, 2024
0
8
Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs) are remarkably long-lived. HSCs are blood-forming cells—they give rise to rapidly dividing progenitor cells, which in turn ...
Cell & Microbiology
Apr 30, 2024
0
60
Scientists have combined laser 3D printing technology and an alternate soaking process to construct complex 3D structures that mimic bone microstructure. This is the first demonstration of this fabrication method, and it ...
Biochemistry
Feb 12, 2024
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64
Blood cells make up the majority of cells in the human body. They perform critical functions and their dysfunction is implicated in many important human diseases, from anemias to blood cancers like leukemia. The many types ...
Cell & Microbiology
Jan 31, 2024
0
53
A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, providing a valuable new insight in the effort to create patient-derived blood stem cells ...
Cell & Microbiology
Dec 19, 2023
0
96
A research team led by Professor Megumu K. Saito (Department of Clinical Application) examined the dynamic transcriptional and epigenetic landscape during definitive hematopoiesis and revealed the non-redundant roles of ZEB2 ...
Cell & Microbiology
Oct 18, 2023
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10
A readily available, inexpensive, small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside the body, potentially improving the success of procedures such as ...
Cell & Microbiology
Sep 27, 2023
0
1
Myelotoxicity is the primary dose-limiting effect of the commonly used chemotherapeutic agent 5-fluorouracil (5-FU), which may endanger the life of the patient. Ribosome biogenesis is a key pathway regulating hematopoietic ...
Cell & Microbiology
Aug 8, 2023
0
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