Balance is key to many physiological functions and it is especially true in the production and regulation of proteins. A balance of proteins in cells helps maintain health, but an unhealthy clumping can lead to a variety ...
Cell & Microbiology
Nov 6, 2017
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145
Whitehead Institute researchers have determined how the master transcriptional regulator of the heat shock response, known as heat shock factor 1 (HSF1), is activated and controlled. This insight could lead to treatments ...
Cell & Microbiology
Nov 14, 2016
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5
Studies at The University of Texas Health Science Center at San Antonio are providing basic new understanding about "heat shock proteins," also called "chaperone proteins." These proteins, first identified in cells subjected ...
Cell & Microbiology
Aug 5, 2016
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39
In one fell swoop, Cornell researchers have discovered mechanisms that control the function of a fat and obesity gene while at the same time answering a long-standing question about how cells respond to stress.
Cell & Microbiology
Oct 29, 2015
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856
Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction. Reporting in ...
Cell & Microbiology
Sep 10, 2015
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16
Cellular repair systems can dissolve aggregated proteins and now Heidelberg researchers have successfully decoded the fundamental mechanism that is key to dissolving these protein aggregates in human cells. Their in-vitro ...
Cell & Microbiology
Aug 12, 2015
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99
New research from the University of Central Florida has shed light on the workings of a particular protein found in the human body that could have future implications for the treatment of cancer and neurodegenerative conditions.
Biochemistry
Aug 7, 2015
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47
Why offspring cope better with climate change - it's all in the genes!
Environment
Jul 20, 2015
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45
Workhorse molecules called heat-shock proteins contribute to refolding proteins that were once misfolded and clumped, causing such disorders as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. ...
Cell & Microbiology
Jan 22, 2015
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60
"Protein misfolding" diseases such as cystic fibrosis and Alzheimer's may be seriously exacerbated by the body's own response against that misfolding, according to a new study led by scientists at The Scripps Research Institute ...
Cell & Microbiology
Nov 18, 2014
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