A model to decipher the complexity of gene regulation

How, where and when genes are expressed determine individual phenotypes. If gene expression is controlled by many regulatory elements, what, ultimately, controls them? And how does genetic variation affect them? The SysGenetiX ...

Flies smell through a Gore-Tex system

A research group led by a scientist of the RIKEN Center for Biosystems Dynamics Research (BDR) has gained important insights into the nanopores that allow the fruit fly to detect chemicals in the air, and has identified the ...

Research offers new insights into malaria parasite

A team of researchers led by a University of California, Riverside, scientist has found that various stages of the development of human malaria parasites, including stages involved in malaria transmission, are linked to epigenetic ...

The cryo-electron microscopy structure of huntingtin

Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. They lead to an incorrect form of the correspondent protein. With the help of cryo-electron microscopy researchers from the Max Planck ...

Rethinking transcription factors and gene expression

Transcription—the reading of a segment of DNA into an RNA template for protein synthesis—is fundamental for nearly all cellular processes, including growth, responding to stimuli, and reproduction. Now, Whitehead Institute ...

The birth of a new protein

A yeast protein that evolved from scratch can fold into a three-dimensional shape—contrary to the general understanding of young proteins—according to new research led by the University of Arizona.

Scientists untangle Barr body of inactive X chromosome

Scientists at UMass Medical School, the Institut Curie in Paris and Stanford University, have taken a detailed look inside the small, densely packed structure of the inactive X chromosome found in female mammals called the ...

True love: How transcription factors interact to create a heart

Scientists at the Gladstone Institutes have discovered that three transcription factors—proteins that direct gene expression—interact with each other and the genome to influence how a heart forms in an embryo. Without ...

Gene crowding affects cell development

The crowding of genes inside the nucleus of a cell affects the way they replicate, and how they are turned on and off, according to a study led by the Liggins Institute at the University of Auckland.

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