Scientists at A*STAR's Genome Institute of Singapore (GIS), in collaboration with their counterparts from Canada, Hong Kong and US, have discovered a protein mediator SON plays a critical role in the health and proper functioning ...
Cell & Microbiology
Sep 9, 2013
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There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a Cold Spring Harbor Laboratory (CSHL) study on RNA splicing, a cellular editing process. The rule-flaunting ...
Biotechnology
May 17, 2012
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A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his ...
Cell & Microbiology
Aug 21, 2013
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A research team at Children's Hospital of Philadelphia (CHOP) has developed an innovative computational tool offering researchers an efficient method for detecting the different ways RNA is pieced together (spliced) when ...
Molecular & Computational biology
Mar 25, 2019
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204
(Phys.org)—Scientists on the Florida campus of The Scripps Research Institute have designed a compound that shows promise as a potential therapy for one of the diseases closely linked to fragile X syndrome, a genetic condition ...
Biochemistry
Sep 4, 2012
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Many types of mushroom have two different nuclei in their cells, one from the 'father' and another from the 'mother." Researchers at the universities of Delft, Utrecht and Wageningen have discovered that the genes from the ...
Plants & Animals
Apr 12, 2018
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45
Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production. Their study appears in the ...
Cell & Microbiology
Sep 23, 2010
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A major puzzle of biology is that while the human genome contains roughly 20,000 genes, many comparatively primitive organisms—including the universally-studied worm C. elegans—have almost the same number of genes.
Biotechnology
Mar 23, 2023
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133
In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the mechanism behind regulated ...
Evolution
Nov 19, 2021
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19
RNA splicing is a major underlying factor that links mutations to complex traits and diseases, according to an exhaustive analysis of gene expression in whole genome and cell line data. Reporting in Science on April 29, 2016 ...
Cell & Microbiology
Apr 28, 2016
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