G-protein coupled receptors (GPCRs) are the "inbox" of environmental messages in mammalian cells. Because of their central role in signaling pathways, mutations resulting in abnormal GPCR functions cause a wide variety of ...
Molecular & Computational biology
Apr 15, 2019
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"Pain begone!" In order to send out this signal, the human body produces tiny messenger molecules that dock to certain receptors. Using traditional biochemical methods, this interaction between the messengers, so-called enkephalins, ...
Biochemistry
Jul 9, 2013
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Last year's Nobel Prize in Chemistry – shared by Stanford School of Medicine Professor Brian Kobilka and Robert Lefkowitz of Duke University – recognized groundbreaking research in G protein-coupled receptors (GPCRs). ...
General Physics
May 10, 2013
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For most of the 20th century, scientists were puzzled by how cells in our body are able to sense and react to external conditions.
Biochemistry
Oct 10, 2012
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A new study in the Journal of General Physiology (JGP) shows that the contribution of odorant receptors (ORs) to olfactory response in mammals is much more complex than previously thought, with important consequences for ...
Plants & Animals
Oct 25, 2010
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1
New data on signaling proteins, called G proteins, may prove important in fighting diseases such as cardiovascular, neurodegenerative disorders, and cancer. For many decades scientists have puzzled on "How signaling proteins ...
Biochemistry
Sep 21, 2009
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Hormones and other neurotransmitters, but also drugs, act upon receptors. "Their active substances bind to the receptors and modify the three-dimensional receptor arrangement regulating the downstream signal pathways," says ...
Biochemistry
Sep 6, 2018
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5
Researchers at the Ruhr Universität Bochum have developed a new method for attaching proteins to the surface of germanium crystals – for the first time also membrane proteins. This enables time-resolved tracking of the ...
Materials Science
Mar 8, 2013
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