Histone modifications are the influencers of zygotic genome awakening

The zebrafish is an important model organism in biology. Humans and zebrafish share 70 percent of their genes, and more than 80 percent of human genes associated with disease are known to have a zebrafish counterpart. Additionally, ...

Spatial DNA organization forms first, then the rest

The fundamental organization of the DNA in active and inactive compartments arises immediately after fertilization of the oocyte, even before genes are activated. This was discovered by researchers from the Hubrecht Institute ...

How cytoplasm separates from yolk

The segregation of yolk from the surrounding cytoplasm in the very early fish embryo is a key process for the development of fish larva. To identify its underlying mechanisms, biologists at the Institute of Science and Technology ...

Cells find their identity using a mathematically optimal strategy

Organisms are made of many types of cells arranged in a precise and reproducible spatial pattern that gives rise to properly formed and well-functioning tissues and organs. But how do genetically identical cells in an organism ...

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