Experimental evolution reveals how bacteria gain drug resistance

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in experimentally evolving the common bacteria Escherichia coli under pressure from a large number of individual antibiotics. ...

Clearing the course for glycans in development of flu drugs

There is no hole-in-one drug treatment when it comes to the flu, but that doesn't stop scientists from trying to sink one. Especially since as many as one in five Americans gets the flu. The reported estimated cost of this ...

How the TB bacterium develops rapid resistance to antibiotics

For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to antibiotics so quickly, in a ...

Antibacterial prodrug by targeting intracellular metabolite

National University of Singapore researchers have developed an approach to selectively target pathogenic bacteria by harnessing an intracellular metabolite known as formate, abundant in these bacteria, as a new antimicrobial ...

Computer model identifies drug-resistant mutations

To counter drug resistance, scientists engineer new drugs to "fit" new mutations and thus kill the cancer cell or pathogen. Now, an NIBIB-funded team of Penn State engineers has a new approach for predicting which mutation ...

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