(Phys.org)—Genome editing for purposes of replication and repair is handled by enzymes called endonucleases, which cleave DNA strands at very specific sites. These are called "restriction sites," composed of palendromic ...
(PhysOrg.com) -- Important molecular machines routinely crash into one another while plying their trades on DNA. New research shows that the enzymes that copy DNA before cell division, called replisomes, are the kings of ...
Cell & Microbiology
Feb 10, 2010
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Chemists at New York University and Harvard University have created a bipedal, autonomous DNA "walker" that can mimic a cell's transportation system. The device, which marks a step toward more complex synthetic molecular ...
Biochemistry
Apr 2, 2009
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Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging.
Cell & Microbiology
Apr 17, 2024
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The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease. However, the CRISPR/Cas9 method can also result in unintended ...
Biotechnology
Sep 15, 2023
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Chemotherapy and radiotherapy aim to destroy cancer cells by inducing DNA double-strand breaks—damage that, once inflicted, usually causes the cells to die. But damage to a cell's genetic material also activates a signaling ...
Biochemistry
Jul 27, 2023
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Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, Have taken a close look at one of the ways cells repair broken strands of DNA and discovered details that could help make a ...
Molecular & Computational biology
Jan 5, 2023
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A Rice University lab is leading the effort to reveal potential threats to the efficacy and safety of therapies based on CRISPR-Cas9, the Nobel Prize-winning gene editing technique, even when it appears to be working as planned.
Cell & Microbiology
Oct 24, 2022
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The molecules of life, DNA, replicate with astounding precision, yet this process is not immune to mistakes and can lead to mutations. Using sophisticated computer modeling, a team of physicists and chemists at the University ...
General Physics
May 5, 2022
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DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. ...
Cell & Microbiology
Jul 9, 2021
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