Related topics: cancer cells · chromosomes · dna damage

MCM molecules impede the formation of DNA loops

The entire genomic material of a cell must be packed into a tiny cell nucleus in such a way, that on the one hand, it can be stored in an organized manner and, on the other hand, it can be transcribed, duplicated or repaired ...

Crystal study may resolve DNA mystery

When cells reproduce, the internal mechanisms that copy DNA get it right nearly every time. Rice University bioscientists have uncovered a tiny detail that helps understand how the process could go wrong.

Cryo-EM reveals how '911' molecule helps fix damaged DNA

When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem—a failsafe that is critical to maintaining health and staving off disease.

DNA replication under the microscope

Cryogenic electron microscopy (cryo-EM) has enabled researchers to study how the DNA replication machinery assembles at sites where DNA is damaged.

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