Damage to DNA is a constant threat to cellular life, and so it is constantly monitored and detected by a family of enzymes called RNA polymerases, resulting in subsequent repair to maintain genome integrity. In a paper published ...
Biotechnology
Aug 22, 2018
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DNA evolved to store genetic information, but in principle this special, chain-like molecule can also be adapted to make new materials. Chemists at The Scripps Research Institute (TSRI) have now published an important demonstration ...
Materials Science
Oct 11, 2017
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385
An team of Rutgers University scientists led by Richard H. Ebright and Eddy Arnold has determined the three-dimensional structure of the transcription initiation complex, the key intermediate in the process by which cells ...
Cell & Microbiology
Oct 18, 2012
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Like an impossibly twisted telephone cord, DNA, the molecule that encodes genetic information, also often finds itself twisted into coils. This twisting, called supercoiling, is caused by enzymes that travel along DNA's helical ...
Cell & Microbiology
Jun 28, 2013
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Indiana University biologists have found that specific types of RNA polymerase enzymes, the molecular machines that convert DNA into RNA, can differ in function based on variation in the parts -- in this case protein subunits ...
Biotechnology
Mar 1, 2012
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One of the earliest events that changes a normal cell into a malignant one is known as deoxyribonucleic acid (DNA) hypermethylation, a biochemical alteration that inactivates critical tumor-suppressor genes. A team of investigators ...
Bio & Medicine
Jul 23, 2009
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Every cell in your body carries the same genetic instructions, and yet cells don't accidentally turn into bone inside your heart, and teeth don't grow in your brain. This is thanks to systems of precise control over the expression ...
Biochemistry
Sep 15, 2015
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116
A pair of chemists at the University of Groningen in the Netherlands, has observed communication between rotors in a molecular motor. In their study, reported in the Journal of the American Chemical Society, Carlijn van Beek ...
(PhysOrg.com) -- A research team has made precise measurements of where and how RNA polymerase encounters obstacles while it reads nucleosomal DNA.
Cell & Microbiology
May 14, 2010
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(PhysOrg.com) -- Important molecular machines routinely crash into one another while plying their trades on DNA. New research shows that the enzymes that copy DNA before cell division, called replisomes, are the kings of ...
Cell & Microbiology
Feb 10, 2010
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